Biopsy of non-healing leg ulcers

Systematic biopsy of chronic leg ulcers not responding to three months or more of appropriate treatment should be considered, the results of a prospective cross-sectional study suggest

Researchers performed at least two 6mm punch biopsies (one at the wound edge and one in the wound bed) in 144 patients who consulted for chronic leg ulcers that were refractory to at least three months' treatment.

Overall skin cancer frequency was 10.4%; 56.3% had persisted for at least three years. Older age, abnormal excessive granulation tissue at wound edges, high clinical suspicion of cancer and number of biopsies were significantly associated with skin cancer in one or more biopsy specimens.
Senet P, Combemale P, Debure C et al. Arch Dermatol 2012

Want news like this straight to your inbox?
Sign up for our bulletins

Read these next

Managing leg ulcers in the community

Managing leg ulcers in the community

Specialised clinics can enhance healing rates and improve...

Prevention of pressure ulcers

Elderly patients admitted to emergency care units are...

Standard care for leg ulcers

A new study has revealed that weekly low-dose high-frequency...

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

MIMS Product Slides

Product overviews prepared by the MIMS team, in a handy slide format.

Click here

Slides are initiated, funded & reviewed by the companies specified.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases