Biopsy of non-healing leg ulcers

Systematic biopsy of chronic leg ulcers not responding to three months or more of appropriate treatment should be considered, the results of a prospective cross-sectional study suggest

Researchers performed at least two 6mm punch biopsies (one at the wound edge and one in the wound bed) in 144 patients who consulted for chronic leg ulcers that were refractory to at least three months' treatment.

Overall skin cancer frequency was 10.4%; 56.3% had persisted for at least three years. Older age, abnormal excessive granulation tissue at wound edges, high clinical suspicion of cancer and number of biopsies were significantly associated with skin cancer in one or more biopsy specimens.
Senet P, Combemale P, Debure C et al. Arch Dermatol 2012

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Calcium and Vitamin D Supplements for Osteoporosis

Calcium and Vitamin D Supplements for Osteoporosis

Formulations, doses and costs of osteoporosis supplements.

Asthma and COPD Preparations and Compatible Devices

Asthma and COPD Preparations and Compatible Devices

Available presentations of bronchodilators and anti-inflammatories.

Topical Steroids, Comparison of Potencies and Formulations

Topical Steroids, Comparison of Potencies and Formulations

Strengths and formulations of topical steroids.

Topical Steroids, Potential Skin Sensitisers as Ingredients

Topical Steroids, Potential Skin Sensitisers as Ingredients

Potential sensitising agents in topical steroids.