Keratinocyte apoptosis in clearance of psoriasis

UK researchers have shown that keratinocyte apoptosis is a key mechanism in clearance of psoriasis

The reserachers investigated the mechanism of action of UVB in clearing psoriatic lesions using wavelengths of 311nm and 290nm. Radiation at 311nm resulted in significant apoptosis, mostly of keratinocytes. The median rate of keratinocyte apoptosis from start to cell death was 20 minutes. The authors created a computational model of the epidermis to determine the clinical relevance of these results and fed the data back into the model. The model confirmed that the level of keratinocyte apoptosis seen was sufficient to confirm the mechanism of the clearance of psoriasis by UVB radiation.
Weatherhead SC, Farr PM, Jamieson D et al. J Invest Dermatol 2011; 131: 1916-26

Want news like this straight to your inbox?
Sign up for our bulletins

Read these next

Dimethyl fumarate in patients with psoriasis

Psoriasis is associated with persistent and maintained...

1.5 CPD credits: Management of chronic plaque psoriasis

Therapeutics have improved, especially with new biological...

Management of scalp psoriasis in primary care

Management of scalp psoriasis in primary care

Patients will be better motivated to persist with treatment...

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

MIMS Product Slides

Product overviews prepared by the MIMS team, in a handy slide format.

Click here

Slides are initiated, funded & reviewed by the companies specified.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases