Emollients and skin barrier function

A small study has found that Aqueous Cream BP can cause damage to the skin barrier in patients with a predisposition to atopic dermatitis and should therefore not be used as a leave-on emollient in such cases

The authors applied Aqueous Cream BP twice daily to the forearms of 13 volunteers for four weeks. They found that its application resulted in significant increase in transepidermal water loss and decrease in integrity of the stratum corneum. Aqueous Cream BP therefore negatively affected the skin barrier, which could lead to disease flares.
Danby SG, Al-Enezi T, Sultan A et al. Br J Dermatol 2011; 165: 329-34
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