Prevention of melanoma development

Researchers from the US have discovered a topical treatment with the potential to prevent the development of invasive metastatic melanoma

Early development of melanocytic lesions is known to involve deregulated PI3 and MAP kinase pathways and no agents exist to target these. The study used a selenium-containing analogue of a urea derivative to prevent melanocytic lesion or melanoma development. In laboratory-generated skin, it reduced lesion development by 70-80 per cent and in animal skin, by about 50 per cent.

Chung CY, Madhunapantula SV, Desai D et al. Cancer Prev Res 2011

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