Early development of melanocytic lesions is known to involve deregulated PI3 and MAP kinase pathways and no agents exist to target these. The study used a selenium-containing analogue of a urea derivative to prevent melanocytic lesion or melanoma development. In laboratory-generated skin, it reduced lesion development by 70-80 per cent and in animal skin, by about 50 per cent.
Chung CY, Madhunapantula SV, Desai D et al. Cancer Prev Res 2011