Metformin in endometrial cancer

Researchers from the University of Warwick have found that metformin, a drug commonly used in diabetes and polycystic ovary syndrome, could offer protection against endometrial cancer

Many women with polycystic ovary syndrome (PCOS) also have endometrial hyperplasia, which predisposes them to endometrial cancer.

These researchers investigated the effects of treatment with metformin on endometrial adenocarcinoma cells. They found endometrial cancer cells were less invasive in the serum of women with PCOS who had taken metformin for six months compared with control subjects.

The proliferation rate of endometrial cancer cells was also lower in the serum of women treated with metformin than those with PCOS who had not been treated. Metformin could have potential as adjuvant therapy in endometrial cancer.
Tan BK, Adya R, Chen J et al. J Clin Endocr Metab 2011

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