Chemopreventive effects of NSAIDs and statins in melanoma

The chemopreventive effects of NSAIDs and statins in melanoma were investigated in this prospective case-controlled study

A total of 400 patients with cutaneous melanoma and 600 controls were interviewed and the association between exposure to NSAIDs or statins and cutaneous melanoma assessed.

The authors analysed current and previous use of medication, risk factors for cutaneous melanoma and demographic characteristics. They found that use of any NSAID for more than five years significantly reduced the risk of melanoma developing (OR 0.57, 95% CI 0.43-0.77); the risk was particularly reduced with use of aspirin. Statin use did not protect against cutaneous melanoma. Further studies of the role of aspirin and other NSAIDs are warranted.
Curiel-Lewandrowski C, Nijsten T, Gomez ML et al. J Invest Dermatol 2011

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