This retrospective cohort study included 11 infants with early white discoloration of infantile haemangioma; sensitivity and specificity of the white discoloration in relation to ulceration were estimated.
In addition, 55 infants with infantile haemangioma were evaluated from a photographic archive to explore the development of ulceration. The average age at first ulceration in the group with early white discoloration was 2.6 months and progression could not be halted.
Fourteen of the 55 infants had white discoloration and 12 of these developed ulceration. Lack of white discoloration reflected low risk of ulceration.
Maguiness SM, Hoffman WY, McCalmont TH et al. Arch Dermatol 2010; 146: 1235-9