Treatment of anal intraepithelial neoplasia

Anal intraepithelial neoplasia is common among HIV-positive men and a potential precursor of anal cancer

In this prospective pilot study, researchers investigated the safety and efficacy of topical treatment with 5FU in this group of patients.

The study included 46 men with grade 1-3 anal intraepithelial neoplasia who were treated with 5FU twice weekly for 16 weeks. Patients were followed up after 6 months.

A total of 18 patients had a complete response, 8 had a partial response and 17 did not respond to treatment. After 6 months, 50% of complete responders experienced recurrence.

The authors conclude that a substantial proportion of HIV-positive men with anal intraepithelial neoplasia respond to treatment with topical 5FU.
Richel O, Wieland U, de Vries HJC et al. Br J Dermatol 2010; 163: 1301-7

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