Ischaemic wound healing

Impaired healing and hypoxia are characteristics of ischaemic wounds

Researchers investigated the pathophysiology of poor wound healing by switching oxygen levels from 21% to 2% in myofibroblasts, the cells essential for the repair process.

Cell culture for 5 days at 2% oxygen represents hypoxia and significantly reduced myofibroblast differentiation and contraction. On switching from high to low oxygen, alpha-smooth muscle actin disassembly from stress fibres occurred as a result of reduced myofibroblast contraction. Restoring high oxygen reversed these effects.

The authors propose that ischaemic wound healing could be improved by supporting myofibroblast formation.
Modarressi A, Pietramaggiori G, Godbout C et al. J Invest Dermatol 2010; 130: 2818-27

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Drug shortages - live tracker

Drug shortages - live tracker

Check on the latest drug supply issues with MIMS' shortages...

Novel MS drug gains NICE approval

Novel MS drug gains NICE approval

New NICE guidance recommends ocrelizumab (Ocrevus)...

Emollients, Potential Skin Sensitisers as Ingredients

Emollients, Potential Skin Sensitisers as Ingredients

Potential sensitising agents in emollient preparations.

NICE recommends new triple therapy option for diabetes

NICE recommends new triple therapy option for diabetes

Ertugliflozin (Steglatro) can now be prescribed routinely...