The genetics of metastasis are poorly understood, although researchers from the US have now identified mutations in a gene responsible for metastasis in uveal melanoma of the eye.
While investigating metastatic uveal melanomas of the eye, the researchers identified mutations in the gene encoding BRCA1-associated protein (BAP1) in 84% of metastasising tumours.
This research suggests that the BAP1 pathway could be a valuable therapeutic target in uveal melanoma metastasis.
Harbour JW, Onken MD, Roberson EDO et al. Science 2010