BAP1 mutation in metastatic uveal melanoma

Malignant melanoma is highly unpredictable, with the potential to metastasise to any organ

The genetics of metastasis are poorly understood, although researchers from the US have now identified mutations in a gene responsible for metastasis in uveal melanoma of the eye.

While investigating metastatic uveal melanomas of the eye, the researchers identified mutations in the gene encoding BRCA1-associated protein (BAP1) in 84% of metastasising tumours.

This research suggests that the BAP1 pathway could be a valuable therapeutic target in uveal melanoma metastasis.
Harbour JW, Onken MD, Roberson EDO et al. Science 2010

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