BAP1 mutation in metastatic uveal melanoma

Malignant melanoma is highly unpredictable, with the potential to metastasise to any organ

The genetics of metastasis are poorly understood, although researchers from the US have now identified mutations in a gene responsible for metastasis in uveal melanoma of the eye.

While investigating metastatic uveal melanomas of the eye, the researchers identified mutations in the gene encoding BRCA1-associated protein (BAP1) in 84% of metastasising tumours.

This research suggests that the BAP1 pathway could be a valuable therapeutic target in uveal melanoma metastasis.
Harbour JW, Onken MD, Roberson EDO et al. Science 2010

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Flu antivirals approved for NHS prescribing as cases increase

Flu antivirals approved for NHS prescribing as cases increase

GPs can now prescribe antiviral medicines for flu prophylaxis...

Emollients, Potential Skin Sensitisers as Ingredients

Emollients, Potential Skin Sensitisers as Ingredients

Potential sensitising agents in emollient preparations.

New e-cigarette alternative launched on prescription

New e-cigarette alternative launched on prescription

Voke, a new nicotine inhaler, is available to prescribe...

Smoking Cessation Treatment Options

Smoking Cessation Treatment Options

Types and suitabilities of smoking cessation treatments.