This longitudinal study followed the change in cardiovascular risk factors in patients starting treatment for psoriasis vulgaris over 12 weeks.
The study included 34 psoriasis patients (10 of whom received topical treatment, 11, narrow-band UVB radiation, and 13, PUVA) and 37 healthy controls. At baseline, patients with psoriasis had higher CRP, oxidised LDL and LDL than control subjects and no significant difference in lipid profile was observed following treatment.
Treatment with topical therapy resulted in reduced thiobarbituric acid reactivity, narrow-band UVB therapy resulted in consistently higher oxidised LDL/LDL, cholesterol/HDL, lipoprotein (a) and CRP than in controls and PUVA resulted in significant reduction in lipoprotein (a) and increase in apolipoprotein-B.
Patients with psoriasis undergo several lipid profile changes and those undergoing narrow-band UVB and PUVA have several cardiovascular risk factors.
Coimbra S. Am J Clin Dermatol 2010; 6: 423-32