In this case-control study, the researchers calculated the age-adjusted incidence of neurological disease in 90 patients with bullous pemphigoid and 141 controls. They found that 46% of patients had at least 1 neurological diagnosis, compared with 11% of controls.
Of the 4 major neurological diagnoses – cerebrovascular disease, dementia, Parkinson's disease and epilepsy – the first 2 were statistically significantly linked to bullous pemphigoid.
Analysis of the interval between the diagnosis of neurological disease and bullous pemphigoid revealed that the median time between neurological disease and bullous pemphigoid was 5.5 years in 72% of patients.
Taghipour K, Chi C, Vincent A et al. Arch Dermatol 2010; 146: 1251-4