Analgesic inhaler launched for use in trauma patients

Trauma patients with moderate to severe pain can now be given an inhaler to relieve their symptoms.

Penthrox can be used in patients with minor trauma, such as fractures, lacerations, burns, dislocations and contusions. | iSTOCK
Penthrox can be used in patients with minor trauma, such as fractures, lacerations, burns, dislocations and contusions. | iSTOCK

Penthrox (methoxyflurane) is suitable for use in conscious adults, who can self-administer the drug in an emergency under the supervision of a healthcare professional.

Further information
View Penthrox drug record 
Summary of Product Characteristics
Manufacturer: Galen

Methoxyflurane is a halogenated hydrocarbon anaesthetic that provides analgesia when inhaled at low concentrations. It should not be used in patients with a history of hepatotoxic reactions to halogenated hydrocarbon anaesthetics or a family history of malignant hyperthermia.

In a randomised, double-blind, placebo-controlled study in 300 patients presenting to emergency departments with minor trauma, methoxyflurane reduced pain intensity significantly more than placebo (p<0.0001) when assessed at 5, 10, 15 and 20 minutes after inhalation. The greatest estimated treatment effect (adjusted change from baseline -18.5 mm) was seen at 15 minutes after the start of treatment.

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