Aflibercept Solution for Injection for Treating Wet Age-Related Macular Degeneration (TA294)

Technology Appraisal Guidance No. 294

Source: National Institute for Health and Care Excellence

 1. Guidance

1.1 Aflibercept solution for injection is recommended as an option for treating wet age related macular degeneration only if: 

  • it is used in accordance with the recommendations for ranibizumab in NICE technology appraisal guidance 155 (re issued in May 2012) and
  • the manufacturer provides aflibercept solution for injection with the discount agreed in the patient access scheme.

1.2 People currently receiving aflibercept solution for injection whose disease does not meet the criteria in 1.1 should be able to continue treatment until they and their clinician consider it appropriate to stop.

The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email:

Aflibercept solution for injection for treating wet age-related macular degeneration.

Issue Date: July 2013

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