Afinitor (everolimus) is indicated for the treatment of advanced renal cell carcinoma that has progressed during or after VEGF-targeted therapy.

Everolimus inhibits mTOR (mammalian target of rapamycin), a serine/threonine kinase that regulates a variety of key cellular processes and is upregulated in several types of cancer.

In a Phase III trial in 416 patients with metastatic renal cell carcinoma whose disease had progressed despite VEGF-targeted treatment with sunitinib and/or sorafenib, the median duration of progression-free survival was 4.9 months on everolimus compared with 1.9 months on placebo.

Afinitor is not recommended for patients with severe hepatic impairment.

View Afinitor drug record

Further information: Novartis

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