Afinitor

Afinitor (everolimus) is indicated for the treatment of advanced renal cell carcinoma that has progressed during or after VEGF-targeted therapy.

Everolimus inhibits mTOR (mammalian target of rapamycin), a serine/threonine kinase that regulates a variety of key cellular processes and is upregulated in several types of cancer.

In a Phase III trial in 416 patients with metastatic renal cell carcinoma whose disease had progressed despite VEGF-targeted treatment with sunitinib and/or sorafenib, the median duration of progression-free survival was 4.9 months on everolimus compared with 1.9 months on placebo.

Afinitor is not recommended for patients with severe hepatic impairment.

View Afinitor drug record

Further information: Novartis

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Live updates: Coronavirus (COVID-19) in the UK

Live updates: Coronavirus (COVID-19) in the UK

Use our timeline to follow the latest coronavirus developments...

MIMS supplement on asthma and COPD

MIMS supplement on asthma and COPD

The June issue of MIMS includes a special supplement...

Drug shortages - live tracker

Drug shortages - live tracker

Use our constantly updated shortages tracker to check...

New antiviral treatment cuts COVID-19 mortality

New antiviral treatment cuts COVID-19 mortality

A combination of two monoclonal antibodies significantly...