Afinitor

Afinitor (everolimus) is indicated for the treatment of advanced renal cell carcinoma that has progressed during or after VEGF-targeted therapy.

Everolimus inhibits mTOR (mammalian target of rapamycin), a serine/threonine kinase that regulates a variety of key cellular processes and is upregulated in several types of cancer.

In a Phase III trial in 416 patients with metastatic renal cell carcinoma whose disease had progressed despite VEGF-targeted treatment with sunitinib and/or sorafenib, the median duration of progression-free survival was 4.9 months on everolimus compared with 1.9 months on placebo.

Afinitor is not recommended for patients with severe hepatic impairment.

View Afinitor drug record

Further information: Novartis

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

More from MIMS

Drug shortages - live tracker

Use our constantly updated shortages tracker to check...

New products - live tracker

EXCLUSIVE TO SUBSCRIBERS See the latest products added...

A woman leans on a desk holding her stomach in pain.

Draft NICE approval for new fibroid treatment

Around 4500 women in England and Wales will be eligible...

Drug price changes - live tracker

EXCLUSIVE TO SUBSCRIBERS Use our constantly updated...