Abiraterone for Castration-Resistant Metastatic Prostate Cancer Previously Treated with a Docetaxel-Containing Regimen (TA259)

Technology Appraisal Guidance No. 259

Source: National Institute for Health and Care Excellence

1. Guidance

1.1 Abiraterone in combination with prednisone or prednisolone is recommended as an option for the treatment of castration-resistant metastatic prostate cancer in adults, only if:

  • their disease has progressed on or after one docetaxel-containing chemotherapy regimen, and
  • the manufacturer provides abiraterone in accordance with the commercial access arrangement as agreed with NHS England.

1.2 People currently receiving abiraterone in combination with prednisone or prednisolone whose disease does not meet the criteria in 1.1 should be able to continue therapy until they and their clinician consider it appropriate to stop.


The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at http://guidance.nice.org.uk/TA259

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email:nice@nice.org.uk

Abiraterone for castration-resistant metastatic prostate cancer previously treated with a docetaxel-containing regimen

Issue Date: June 2012 (updated July 2016)


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