Zyclara: new strength of imiquimod for actinic keratosis

Zyclara (imiquimod) is a cream for the topical treatment of non-hyperkeratotic and non-hypertrophic actinic keratosis of the face and scalp. It is indicated for use when other topical treatment options are contraindicated or less appropriate.

Zyclara should remain on the skin for approximately 8 hours.
Zyclara should remain on the skin for approximately 8 hours.


Imiquimod is an immune response modifier that has been shown to increase systemic levels of interferon alfa and other cytokines following topical application.1


The safety and efficacy of imiquimod were evaluated in two double-blind, placebo-controlled studies involving 319 patients with five to 20 typical visible or palpable AK lesions of more than 25cm2 on the face or scalp.2

Up to two sachets of imiquimod 3.75% cream or a matching vehicle cream were applied to the entire face or balding scalp once daily for two 2-week treatment cycles separated by a 2-week treatment-free period.2

Overall, 35.6% of patients treated with imiquimod 3.75% cream had complete clearance eight weeks post-treatment compared with 6.3% of those treated with placebo.2

The most commonly reported side-effects are application site reactions, including erythema, scabbing, exfoliation and dryness.1


1.    Zyclara Summary of Product Characteristics, August 2012.
2.    Swanson N et al. J Am Acad Dermatol 2010; 62: 582–90.

View Zyclara drug record

Further information: Meda Pharmaceuticals Ltd

Follow MIMS on Twitter

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases