Tyrosine kinase inhibitor for kidney cancer

Votrient (pazopanib) is indicated for the treatment of advanced renal cell carcinoma (RCC), both as first-line treatment and following previous cytokine therapy.

Pazopanib is a potent inhibitor of multiple tyrosine kinases: vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, platelet-derived growth factor receptors (PDGFR)-α and –β, and stem cell factor receptor (c-KIT). By inhibiting angiogenesis, pazopanib deprives kidney tumour cells of their oxygen supply.

In a randomised, double-blind, multicentre study in 435 patients with locally advanced and/or metastatic RCC, median progression-free survival was 9.2 months with pazopanib 800mg daily compared with 4.2 months on placebo, equating to a 54 per cent relative reduction in the risk of disease progression with pazopanib (p<0.0001).

View Votrient drug record

Further information: GlaxoSmithKline

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