Sayana Press: long-acting reversible contraceptive for subcutaneous injection

Sayana Press (medroxyprogesterone acetate) is the first subcutaneously-administered depot contraceptive to be launched in the UK.

Sayana Press (medroxyprogesterone acetate) is supplied in a prefilled injection device ready to be injected under the skin into the thigh or abdomen.
Sayana Press (medroxyprogesterone acetate) is supplied in a prefilled injection device ready to be injected under the skin into the thigh or abdomen.


Sayana Press is a subcutaneous formulation of medroxyprogesterone acetate, which inhibits the secretion of gonadotrophins, thereby preventing follicular maturation and ovulation. Endometrial thinning also occurs as a result of ovulation suppression. 1


The contraceptive efficacy of medroxyprogesterone acetate (104mg/0.65ml) injected subcutaneously every 3 months was assessed in two phase III open-label non-comparator studies involving 1,787 women aged 18 to 49 years.2

Women recruited to the study were required to be sexually active and included those who had used oral, intrauterine or barrier methods of contraception previously. Women were excluded if they had used any of these contraceptive methods within the 2 months before enrolment or had received an intramuscular injection of medroxyprogesterone within 10 months before enrolment.2

Zero pregnancies at end of year 1

The cumulative pregnancy rate at 1 year (the primary efficacy endpoint) was zero, as was the Pearl Index (number of pregnancies per 100 woman years of use).2

Another phase III, evaluator-blinded study (n=534) compared the contraceptive efficacy and changes in bone mineral density (BMD) associated with medroxyprogesterone acetate given subcutaneously (104mg) or intramuscularly (150mg, as Depo-Provera®) every 3 months for 2 years.3

After 2 years, women had the option to continue in the study for a further year with the same medroxyprogesterone formulation they had been receiving, or to discontinue treatment.3

The cumulative pregnancy rate at 2 years was zero in the subcutaneous group and 0.8% in the intramuscular group (Pearl Indices 0 vs 0.35, respectively). These values remained unchanged at 3 years.3

Safety data

The observed median BMD decreases from baseline at the total hip and lumbar spine at 2 years and 3 years were slightly smaller in the subcutaneous group than in the intramuscular group (-3.3% vs -3.6%, respectively at the total hip and -4.3% vs .5.0%, respectively at the lumbar spine). However, the differences were not significant.3

Mean weight gain from baseline was similar for women receiving medroxyprogesterone by the subcutaneous or intramuscular routes (3.4kg versus 3.5kg at the end of year 2 and 4.5kg versus 5.8kg at the end of year 3).3

Subcutaneous medroxyprogesterone was well tolerated in all three studies.2,3


  1. Sayana Press Summary of Product Characteristics, September 2012.
  2. Jain J et al. Contraception 2004; 70: 269–75.
  3. Kaunitz AM et al. Contraception 2009; 80: 7–17.

View Sayana drug record

Further information: Pfizer

Follow MIMS on Twitter

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases