Psychiatric advice issued for psoriasis treatment

The prescribing information for apremilast (Otezla) has been updated with warnings relating to suicidal ideation and behaviour.

Apremilast is an oral treatment for psoriasis and psoriatic arthritis. | SCIENCE PHOTO LIBRARY
Apremilast is an oral treatment for psoriasis and psoriatic arthritis. | SCIENCE PHOTO LIBRARY

In a letter to healthcare professionals, the manufacturer of apremilast has advised that the drug should be used with caution in patients with a history of psychiatric symptoms or in those taking medications that may cause psychiatric symptoms.

Patients and carers should be advised to report any changes in behaviour or mood or any signs of suicidal ideation. Treatment should be discontinued if new or worsening psychiatric symptoms occur, or suicidal ideation or attempts are identified.

Analysis of postmarketing data for apremilast up to 20th March 2016 revealed 65 cases of suicidal ideation and behaviour (in patients with or without a history of depression), including five completed suicides.

Apremilast is indicated for the treatment of moderate to severe chronic plaque psoriasis in adults who have failed to respond to, have a contraindication to, or are intolerant to, other systemic therapy including ciclosporin, methotrexate or PUVA.

Apremilast can also be used, alone or in combination with DMARDs, to treat active psoriatic arthritis in patients with an inadequate response or intolerance to DMARDs.

Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases