Pliaglis: combined local anaesthetic for dermatological procedures

Pliaglis (lidocaine/tetracaine) combined topical cream for surface anaesthesia of skin in dermatological procedures.

Pliaglis is not recommended for use in patients under 18 years of age
Pliaglis is not recommended for use in patients under 18 years of age


Lidocaine and tetracaine are local anaesthetic agents which act by blocking the sodium ion channels required for the initiation and conduction of neuronal impulses.1


The safety and efficacy of lidocaine/tetracaine were evaluated in 12 randomised, double-blind phase III studies (n=669) involving various dermatological procedures and application times.1

The anaesthetic combination and placebo were applied to two comparable areas of skin with pre-treatment contact times of 20 minutes for pulsed dye laser therapy, 30 minutes for dermal filler and collagen injections, laser-assisted hair removal and non-ablative laser resurfacing and 60 minutes for laser-assisted tattoo removal and leg vein ablation.1

Pain was measured using a 100mm Visual Analogue Scale. Treatment with lidocaine/tetracaine resulted in a significant reduction in pain compared with placebo in all instances.1

The lidocaine/tetracaine combination was well tolerated, with erythema, skin discolouration and skin oedema the most common adverse effects.1


  1. Pliaglis Summary of Product Characteristics, September 2012.

View Pliaglis drug record

Further information: Galderma UK Ltd

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