What is chronic pancreatitis?
Chronic pancreatitis is the result of damage to the pancreas, which can result in a number of different causes. These can each result in inflammation of the pancreas, which causes scarring, fibrosis, and sometimes the development of calcium deposits in the gland. The scarring can result both in reducing insulin production from the pancreas and a reduction in enzyme production. This can lead to failure to absorb fats or proteins.
The scarring can cause different problems in different people. In some people, nerves can get irritated, causing pain. In others, the scarring can result in acute attacks of inflammation. In other people, the scarring can produce a lump in the pancreas, which can cause narrowing of the end of the tube between the liver and the bowel (the bile duct). This can result in jaundice. In other patients, the inflammation can produce cysts on the pancreas (pseudocysts). Sometimes, scarring can cause a narrowing in the drainage tube from the pancreas (the pancreatic duct – stricture). Insulin production can drop, causing diabetes.
What causes chronic pancreatitis?
There are many causes of chronic pancreatitis but in the UK, most are associated with alcohol intake. Alcohol is toxic to the pancreas and some people are more susceptible to damage from alcohol than others. Other causes include a follow-on of damage from acute pancreatitis, while some patients develop chronic pancreatitis because of an inherited tendency related to trypsinogen and inhibitory protein defects.
Other causes include cystic fibrosis, trauma and auto-immune problems; in some people who develop chronic pancreatitis, the cause is not understood.
What symptoms do you get?
Chronic pancreatitis causes two main problems. These are chronic pain and pancreatic insufficiency, which means a reduced ability of the pancreas to produce insulin and the enzymes that help to digest fats. There are a number of other problems:
- Reduction in insulin production, which can lead to diabetes.
- Reduction in enzyme secretion – fat malabsorption. This causes stools to become pale and bulky and frequently difficult to flush away. The result is weight loss.
- Chronic pain. This is usually felt in the upper abdomen and back and can vary from mild to very severe and unremitting.
- Recurrent flare-ups of acute inflammation, with sudden onset of upper abdominal pain, vomiting and inflammation.
- Cyst formation. Sometimes, damage to the pancreas can produce cysts on the pancreas (pseudocysts).
- Blockage of the bile duct causing jaundice.
- Blockage of the duodenum causing vomiting.
How is it diagnosed?
The diagnosis of chronic pancreatitis is based on typical clinical features such as fat malabsorption, causing weight loss, characteristic upper abdominal and back pain. Sometimes, these are not present and people can present with recurrent attacks of acute inflammation.
The diagnosis is usually confirmed with tests. These can include imaging such as ultrasound and CT scans. CT scans can reveal various features such as calcification within the pancreas, a lump in the pancreas, dilatation of the pancreatic duct or cyst formation.
Other tests can be helpful to confirm the diagnosis and look more closely into the effects of chronic pancreatitis. These tests include endoscopic ultrasound scanning or magnetic resonance scanning of the pancreas, which can look for narrowing in the pancreatic duct.
There are also tests, which measure the amount of fat that is not being absorbed in the gut.
How can chronic pancreatitis be treated?
The treatment of chronic pancreatitis depends on which problems the chronic pancreatitis is causing, and this can be different in different patients.
Treatment is directed whenever possible to correction of the underlying cause, to relieve pain and correct fat malabsorption and reverse weight loss. Diabetes may occur and will need treatment with drugs or insulin.
The abdominal pain can be quite severe and require treatment with either simple pain killers or sometimes opiates.
To reverse the fat malabsorption, replacement pancreatic enzyme capsules are available.
An endoscope can be used to widen areas of narrowing in the pancreas or to remove stones which can, in a few patients, result in symptom improvement.
Surgery is available in specialised centres for some suitable patients. Two types of operation are commonly employed. These involve removing the most affected part of the pancreas or draining the affected pancreas straight into another part of the bowel. These operations will not help everybody but good results are obtained in six or seven out of ten patients.
Other operations are sometimes required to correct the complications of chronic pancreatitis, such as cyst formation. Cysts sometimes need draining which can be done both surgically and endoscopically depending on the suitability of the cyst.
What research is needed?
Further research is needed on effective pain control in chronic pancreatitis and in better controlling the fat malabsorption that occurs. Research into the cyclical process of inflammation and fibrosis is needed - if this could be controlled it might be possible to prevent the progressive destruction of the pancreas. It is also important to find out why some people who drink alcohol are affected but others who seemingly drink similar amounts have no problems.
Fact sheet produced by Core and provided by MIMS
Last reviewed: July 2013
Core is the charity for research and information on gut and liver disease