Pancreatitis - Acute

What is the Pancreas?

The pancreas is part of the digestive system. It lies in the upper half of the abdomen behind the stomach and in front of the spine. It is a solid flat gland about nine inches long, salmon pink in colour and shaped like a comma.


What does it do?

The pancreas has two main functions. It produces digestive juices (enzymes which help to digest food) and hormones, including insulin (a hormone which balances the sugar in the blood). The digestive juice flows into the duodenum and mixes with the food and bile to digest food. It also produces other hormones, which help with digestion and bicarbonate to balance the acid from the stomach.


What is acute pancreatitis?

Acute pancreatitis is sudden inflammation of the pancreas gland. When the pancreas gets inflamed some of the digestive enzymes produced by the pancreas become active within the gland, causing damage by digesting the pancreas itself. This damage can sometimes be mild, and the gland becomes red, angry and swollen or if more severe, the pancreas, the arteries inside the pancreas or fat surrounding the pancreas can get involved causing swelling and destruction of the tissues. Sometimes the damage can be so bad that the pancreas can lose it’s blood supply and die – this is called necrotizing pancreatitis.

The damage that results from pancreatitis is unpredictable, sometimes minimal, but sometimes extensive, which is why it can be so serious. Fortunately about three quarters of people have the mild form.


What causes acute pancreatitis?

Gallstones and alcohol are the two most common causes.

There are many causes of acute pancreatitis but in the UK, the two most common are gallstones and alcohol. Gallstones cause problems when small stones pass out of the gallbladder into the bile duct and temporarily block the pancreas. Alcohol is a toxin to the pancreas and some people are more susceptible to damage from alcohol than others.

Less common causes include:
  • Following trauma
  • Some viral infections
  • Side effect of some drugs - for example azathioprine and steroids
  • Genetic abnormalities of the enzyme trypsin that is made by the pancreas
  • Pancreas divisum – when the pancreas develops in two halves
  • Hypertriglyceridemia – high fats in the blood
  • Rarely as a complication of pancreas cancer
  • Following endoscopy tests on the pancreas (also rare)
  • And occasionally the cause is never found

What symptoms do you get?

People get sudden onset of abdominal pain, usually starting in the upper abdomen. This can be very severe and be likened to a burst ulcer. The pain, which is often accompanied by vomiting, is usually so severe that a hospital admission is necessary. Usually patients stay 5-10 days in hospital or longer if complications develop.


How is it diagnosed?

The diagnosis of acute pancreatitis is based on the typical symptoms described earlier followed by the finding of tenderness in the upper abdomen. Sometimes this tenderness can be all over. Usually chest and abdominal X-rays are performed and then blood tests. In acute pancreatitis levels of the enzymes, particularly amylase and lipase, that are produced by the pancreas are raised.

An ultrasound scan is usually performed next to determine whether gallstones are present, whether the bile duct is dilated and sometimes the pancreas can be seen to be swollen. A CT scan may be necessary to rule out other possible causes of pain if these tests are not helpful.


How can acute pancreatitis be treated?

Nothing helps to stop the inflammation of acute pancreatitis. Basic treatment such as a drip and oxygen are required and usually a catheter is necessary to monitor urine output. A nasogastric tube is often inserted.

The inflammation can affect other organs, so people with acute pancreatitis can develop problems with their chest and kidneys.

Diabetes may occur and will need treatment with drugs, insulin or other drugs.

The abdominal pain can be severe and needs treatment with opiates like morphine. Although antibiotics can sometimes be necessary, they are not routinely used because pancreatitis is not an infection.

Sometimes people get better quickly and are able to eat and drink within a few days but sometimes tube-feeding is required. Fortunately most people have only mild inflammation and settle, but some develop complications. Sometimes an examination called an ERCP can be required, especially when there is a hold up of bile from the liver or signs of infection in the bile duct (cholangitis).

Once people start getting better then it is very important to search for and treat any underlying cause. For example if gallstones are present these should be removed – usually by laparoscopic cholecystectomy (keyhole removal of the gallbladder). This is best done before a patient with pancreatitis and gallstones goes home or certainly within 2 weeks. If the cause is high alcohol intake then alcohol should be stopped completely. This may require specialised help as it is difficult to do this on your own.


What complications can occur?

  • Low blood pressure or fast heart rate needing intravenous fluid by vein.
  • Breathing problems needing oxygen or rarely breathing support on an intensive care unit.
  • Fluid can develop around the pancreas and sometimes cysts can form. Most of these settle themselves but can sometimes need to be drained.
  • The pancreas can sometimes lose it’s blood supply, either in patches or the whole gland. We call this necrosis. This can be a very serious complication especially if the tissue gets infected. This needs a longer hospital stay – typically 3 months. Transfer to a hospital or team specialising in the treatment of severe acute pancreatitis may be necessary.
  • The disease can be so severe that a minority of patients die: the overall mortality of acute pancreatitis is 5%, rising to 25% if complications develop.

Further research needed

Pancreatitis can cause major illness. Nothing has been found yet which can switch off the inflammation. Research is needed into exactly how the inflammation is triggered in the pancreas cells. Further research is also required into the best way of treating any complications that occur and in preventing these complications if possible.


Fact sheet produced by Core and provided by MIMS

Last reviewed:  July 2013

Core is the charity for research and information on gut and liver disease
www.corecharity.org.uk


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