Jump to:


27 August 2009, 10:30am

Nicotinic acid and laropiprant modified-release tablets for treating dyslipidaemia, particularly combined mixed dyslipidaemia and primary hypercholesterolaemia.



Tredaptive combines nicotinic acid (niacin), a lipid-lowering agent, with laropiprant, a selective antagonist of the prostaglandin D2 receptor subtype 1.1 Laropiprant has no effect on lipid levels, but simply suppresses the flushing caused by nicotinic acid.


In a 24-week trial in 1,216 patients, nicotinic acid (1g/day for four weeks, followed by 2g/day for 20 weeks) given in combination with laropiprant significantly improved lipid profiles compared with placebo and caused markedly less flushing than the same dose of nicotinic acid alone.2

In another trial, the 726 patients randomised to receive nicotinic acid (1g/day for four weeks, followed by 2g/day for 12 weeks) given in combination with laropiprant experienced significantly fewer days of flushing per week during the 16-week treatment period than the 729 patients who were randomised to receive nicotinic acid alone (0.5g/day for four weeks gradually titrated to 2g/day for the final four weeks), despite more rapid nicotinic acid titration.3

View Tredaptive drug record


  1. Tredaptive Summary of Product Characteristics. July 2008.
  2. Maccubbin D, Bays H et al. Lipid-modifying efficacy and tolerability of e-r niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int J Clin Pract 2008: 62; 1959-70.
  3. Maccubbin D, Koren M et al. Flushing profile of e-r niacin/laropiprant versus gradually titrated niacin e-r in patients with dyslipidemia with and without ischemic cardiovascular disease. Am J Cardiol 2009: 104; 74-81.

Further information: MSD


MIMS Specialist Journals

Now available on www.mims.co.uk

Click here to view

7-Part CME IBS Programme

Irritable bowel syndrome medical education programme worth 6.5 CPD credits. Click here to view

MIMS app

Access the full MIMS database from your mobile device

Click here to find out more

MIMs Drug Search

Possible searches include drugs (by brand, generic ingredient or drug class), diseases and more.

Find drugs by:

Travel Vaccination & Malaria Advice

Travel Vaccination & Malaria Advice

Supplied by the National
Travel Health Network
and Centre (NaTHNaC)

Palliative Care Resources

Palliative Care Resources

Opioid dose conversions
and much more

Childhood Immunisation

Childhood Immunisation

Summary of routine
vaccination schedule

Referral Guidelines for Breast Disorders

Referral Guidelines for Breast Disorders

MIMS Summary of NHS Cancer Screening Referral Guidelines

Quick-reference table: antibiotics

Quick-reference table: antibiotics

Treatment regimens for common infections

Back to top