Januvia (sitagliptin) has had its licence extended to include use in triple therapy alongside metformin and a sulfonylurea or a glitazone in type II diabetes inadequately controlled by dual therapy.
The dosage of metformin and glitazone should be maintained and the Januvia dose administered concomitantly.
If it is used in combination with a sulfonylurea, the dose of sulfonylurea may need to be lowered to reduce the risk of hypoglycaemia. The recommended dose of Januvia is 100mg once daily.
Further information: MSD
