Insulin Preparations

Insulin Preparations
Neutral Insulin Injection
Preparation	Manufacturer	Species	Form	Onset (approx.)	Peak activity (approx.)	Duration of Action (approx.)
Actrapid	Novo Nordisk		V	<30 mins	1.5-3.5h	7-8h
Apidra (insulin glulisine)	Sanofi-aventis		V,P,C5, C2	10-20 mins	55 mins	1.5-4h
Humalog (insulin lispro*)	Lilly		V,P,C3,4	15 mins	1.5h	2-5h
Humulin S	Lilly		V,P,C3,4	30 mins-1h	1-6h	6-12h
Hypurin Bovine Neutral	Wockhardt		V,C3	30 mins-1h	1.5-4.5h	6-8h
Hypurin Porcine Neutral	Wockhardt		V,C3	30 mins-1h	1.5-4.5h	6-8h
Insuman Rapid	Sanofi-aventis		P,C5	<30 mins	1-4h	7-9h
NovoRapid (insulin aspart)	Novo Nordisk		V,P,C1	10-20 mins	1-3h	3-5h
Biphasic Insulin Injection**
Preparation	Manufacturer	Species	Form	Onset (approx.)	Peak activity (approx.)	Duration of Action (approx.)
Humalog Mix25	Lilly		P,C3,4	15 mins	2h	22h
Humalog Mix50	Lilly		P,C3,4	15 mins	2h	22h
Humulin M3	Lilly		V,P,C3,4	30 mins-1h	1-12h	22h
Hypurin Porcine 30/70	Wockhardt		V,C3	<2h	4-12h	24h
Insuman Comb 15	Sanofi-aventis		V,P,C5	30 mins-1h	2-4h	11-20h
Insuman Comb 25	Sanofi-aventis		V,P,C5	30mins-1h	2-4h	12-19h
Insuman Comb 50	Sanofi-aventis		V,P,C5	<30 mins	1.5-4h	12-16h
Mixtard 30	Novo Nordisk		V,D,C1	<30 mins	2-8h	24h
NovoMix 30	Novo Nordisk		P,C1	<10-20 mins	1-4h	24h
Isophane Insulin Injection
Preparation	Manufacturer	Species	Form	Onset (approx.)	Peak activity (approx.)	Duration of Action (approx.)
Humulin I	Lilly		V,P,C3,4	30 mins-1h	1-8h	22h
Hypurin Bovine Isophane	Wockhardt		V,C3	<2h	6-12h	18-24h
Hypurin Porcine Isophane	Wockhardt		V,C3	<2h	6-12h	18-24h
Insulatard	Novo Nordisk		V,D,C1	<1.5h	4-12h	24h
Insuman Basal	Sanofi-aventis		V,P,C5	<1h	3-4h	11-20h
Insulin Zinc Suspension (Mixed)
Preparation	Manufacturer	Species	Form	Onset (approx.)	Peak activity (approx.)	Duration of Action (approx.)
Hypurin Bovine Lente	Wockhardt		V	2h	8-12h	30h
Protamine Zinc Insulin Injection
Preparation	Manufacturer	Species	Form	Onset (approx.)	Peak activity (approx.)	Duration of Action (approx.)
Hypurin Bovine PZI	Wockhardt		V	4-6h	10-20h	24-36h
Long-acting insulin analogues
Preparation	Manufacturer	Species	Form	Onset (approx.)	Peak activity (approx.)	Duration of Action (approx.)
Lantus (insulin glargine)	Sanofi-aventis		V,P,C5, C2	2.5h	-	24h
Levemir (insulin detemir)	Novo Nordisk		P,C1, D	2.5h	-	24h

*Insulin lispro=human insulin analogue
**Speed of onset is proportional to amount of soluble insulin.
Key:
V = vial.
P = preloaded pen.
C = cartridge.
C₁ = compatible with NovoPen 3 or NovoPen 4.
C₂ = compatible with OptiClik.
C₃ = compatible with Autopen Classic.
C₄ = compatible with HumaPen Ergo/HumaPen Luxura.
C₅ = compatible with OptiPen Pro 1 and Autopen 24.
D = InnoLet delivery device
Pen needles:
Microfine, NovoFine, Penfine and Unifine are compatible with all preloaded and reusable pens.

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