Jump to:

Nimenrix: new conjugate meningitis vaccine

02 July 2012, 9:18am

Nimenrix is now available for active immunisation against invasive disease caused by Neisseria meningitidis serogroups A, C, W-135 and Y.

Nimenrix is the first quadrivalent meningococcal conjugate vaccine that is approved for use from 1 year of age

Nimenrix is the first quadrivalent meningococcal conjugate vaccine that is approved for use from 1 year of age


Nimenrix is a conjugated quadrivalent meningitis vaccine consisting of four capsular polysaccharide groups conjugated to tetanus toxoid carrier protein. It induces the production of antibodies against capsular polysaccharides of Neisseria meningitidis group A, C, W135 and Y. These antibodies protect against meningococcal disease via complement-mediated bactericidal activity.1


The safety and efficacy of Nimenrix have been evaluated in 17 clinical studies conducted in 17 countries worldwide. Immunogenicity was assessed in six key studies: two studies recruited infants 12–23 months, two studies enrolled children aged 2–10 years of age, and two studies enlisted adolescents aged 11–17 years and adults aged 18–55 years.1

These key studies aimed to demonstrate a non-inferior immunological response to a single dose of Nimenrix compared with a licensed meningococcal vaccine. Serum bactericidal antibody levels were measured by assays using either rabbit or human complement (rSBA or hSBA).1

In all studies, Nimenrix was found to be non-inferior to a licensed meningococcal vaccine in eliciting an immunological response.1

The safety profile of Nimenrix is based on clinical studies involving more than 8,000 patients. The vaccine was generally well tolerated, with the most commonly observed adverse effects including anorexia, irritability, fatigue, drowsiness, headache, fever and injection-site reactions.1


  1. Nimenrix Summary of Product Characteristics, April 2012.

View Nimenrix drug record

Further information: GlaxoSmithKline

You must log in to make full use of all the site content and features.

New users can register here free for full site access.

Related Drug Categories


MIMS Specialist Journals

Now available on www.mims.co.uk

Click here to view

7-Part CME IBS Programme

Irritable bowel syndrome medical education programme worth 6.5 CPD credits. Click here to view

MIMS app

Access the full MIMS database from your mobile device

Click here to find out more

MIMs Drug Search

Possible searches include drugs (by brand, generic ingredient or drug class), diseases and more.

Find drugs by:

Travel Vaccination & Malaria Advice

Travel Vaccination & Malaria Advice

Supplied by the National
Travel Health Network
and Centre (NaTHNaC)

Palliative Care Resources

Palliative Care Resources

Opioid dose conversions
and much more

Childhood Immunisation

Childhood Immunisation

Summary of routine
vaccination schedule

Referral Guidelines for Breast Disorders

Referral Guidelines for Breast Disorders

MIMS Summary of NHS Cancer Screening Referral Guidelines

Quick-reference table: antibiotics

Quick-reference table: antibiotics

Treatment regimens for common infections

Back to top