Insulin Preparations
Quick-reference table for comparison of insulin profiles.
| Insulin Preparations | ||||||
|---|---|---|---|---|---|---|
| Neutral Insulin Injection | ||||||
| Preparation | Manufacturer | Species | Form | Onset (approx) | Peak activity (approx) | Duration of action (approx) |
| Actrapid | Novo Nordisk |  |
V | <30 min | 1.5-3.5hr | 7-8hr |
| Apidra (insulin glulisine) | Sanofi-aventis |  |
V, P, C4, C5 | 10-20 min | 55 min | 1.5-4hr |
| Humalog (insulin lispro*) | Lilly | |
V, P, C2, C3 | 15 min | 1.5hr | 2-5hr |
| Humulin S | Lilly | |
V, C2, C3 | 30 min-1hr | 1-6hr | 6-12hr |
| Hypurin Bovine Neutral | Wockhardt |  |
V, C2 | 30 min-1hr | 1.5-4.5hr | 6-8hr |
| Hypurin Porcine Neutral | Wockhardt |
|
V, C2 | 30 min-1hr | 1.5-4.5hr | 6-8hr |
| Insuman Rapid | Sanofi-aventis | |
P, C4, C5 | <30 min | 1-4hr | 7-9h |
| NovoRapid (insulin aspart) | Novo Nordisk | |
V, P, C1 | 10-20 min | 1-3hr | 3-5hr |
| Biphasic Insulin Injection** | ||||||
| Preparation | Manufacturer | Species | Form | Onset (approx) | Peak activity (approx) | Duration of action (approx) |
| Humalog Mix25 | Lilly | |
V, P, C2, C3 | 15 min | 2hr | 22hr |
| Humalog Mix50 | Lilly | |
P, C2, C3 | 15 min | 2hr | 22hr |
| Humulin M3 | Lilly | |
V, P, C2, C3 | 30 min-1hr | 1-12hr | 22hr |
| Hypurin Porcine 30/70 | Wockhardt |  |
V, C2 | <2hr | 4-12hr | 24hr |
| Insuman Comb 15 | Sanofi-aventis | |
C4, C5 | 30 min-1hr | 2-4hr | 11-20hr |
| Insuman Comb 25 | Sanofi-aventis | |
V, P, C4, C5 | 30min-1hr | 2-4hr | 12-19hr |
| Insuman Comb 50 | Sanofi-aventis | |
C4, C5 | <30 min | 1.5-4hr | 12-16hr |
| NovoMix 30 | Novo Nordisk | |
P, C1 | 10-20 min | 1-4hr | 24hr |
| Isophane Insulin Injection | ||||||
| Preparation | Manufacturer | Species | Form | Onset (approx) | Peak activity (approx) | Duration of action (approx) |
| Humulin I | Lilly | |
V, P, C2, C3 | 30 min-1hr | 1-8hr | 22hr |
| Hypurin Bovine Isophane | Wockhardt |  |
V, C2 | <2hr | 6-12hr | 18-24hr |
| Hypurin Porcine Isophane | Wockhardt |  |
V, C2 | <2hr | 6-12hr | 18-24hr |
| Insulatard | Novo Nordisk | |
V, C1, D | <1.5hr | 4-12hr | 24hr |
| Insuman Basal | Sanofi-aventis | |
V, P, C4, C5 | <1hr | 3-4hr | 11-20hr |
| Insulin Zinc Suspension (Mixed) | ||||||
| Preparation | Manufacturer | Species | Form | Onset (approx) | Peak activity (approx) | Duration of action (approx) |
| Hypurin Bovine Lente | Wockhardt | |
V | 2hr | 8-12hr | 30hr |
| Protamine Zinc Insulin Injection | ||||||
| Preparation | Manufacturer | Species | Form | Onset (approx) | Peak activity (approx) | Duration of action (approx) |
| Hypurin Bovine PZI | Wockhardt | |
V | 4-6hr | 10-20hr | 24-36hr |
| Long-acting Insulin Analogues | ||||||
| Preparation | Manufacturer | Species | Form | Onset (approx) | Peak activity (approx) | Duration of action (approx) |
| Lantus (insulin glargine) | Sanofi-aventis | |
V, P, C4, C5 | 2.5hr | - | 24hr |
| Levemir (insulin detemir) | Novo Nordisk | |
P, C1, D | 2.5hr | - |
24hr |
*Insulin lispro=human insulin analogue
**Speed of onset is proportional to amount of soluble insulin.
Key:
V = vial.
P = preloaded pen.
C = cartridge.
C1 = compatible with NovoPen range.
C2 = compatible with Autopen Classic.
C3 = compatible with HumaPen range.
C4 = compatible with Autopen 24.
C5 = compatible with ClikSTAR.
D = InnoLet delivery device.
Pen needles:
Microfine, Penfine and Unifine are compatible with all preloaded and reusable pens.
KEYWORDS:
Diabetes
