New myeloma treatment provides all-oral regimen option

Ninlaro (ixazomib) is the first proteasome inhibitor to be administered orally.

Taken once weekly in combination with a regimen of lenalidomide and dexamethasone, Ninlaro is indicated in patients with multiple myeloma who have received at least one prior therapy.

In a randomised, double-blind, placebo-controlled pivotal trial in 722 patients with relapsed and/or refractory multiple myeloma, addition of ixazomib to treatment with lenalidomide and dexamethasone was associated with a 40% increase in progression-free survival.

Median progression-free survival was 20.6 months in patients receiving ixazomib plus lenalidomide/dexamethasone compared with 14.7 months in those given placebo plus lenalidomide/dexamethasone (hazard ratio for disease progression or death in the ixazomib group, 0.74; p=0.01).

The rates of serious adverse events, discontinuation due to adverse events, and death during the study period were similar in the two groups.


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