A new combination capsule for BPH

Combodart (dutasteride/tamsulosin) is now available for the management of benign prostatic hyperplasia.

PHARMACOLOGY

Dutasteride delays progression of BPH by inhibiting the production of the hormone dihydrotestosterone (DHT) that stimulates prostate growth. Tamsulosin provides rapid symptom relief by reducing smooth muscle tone in the prostate and bladder neck.

CLINICAL STUDIES

A four-year multicentre, randomised, double-blind study in 4844 men assessed the efficacy of combination therapy with dutasteride and tamsulosin versus monotherapy with either agent in reducing the relative risk of acute urinary retention (AUR), BPH-related surgery, and BPH clinical progression over four years in men at increased risk of progression.

Combination therapy was significantly superior to tamsulosin monotherapy, but not dutasteride monotherapy, at reducing relative risk of AUR or BPH-related surgery. Combination therapy was significantly superior to both monotherapies at reducing the relative risk of BPH clinical progression, and provided greater symptom relief at four years.

Safety and tolerability of combination therapy was consistent with that of monotherapies, except for cardiac failure, which was higher in the combination and tamsulosin groups.1

View Combodart drug record

REFERENCES

  1. Roehrborn C et al. Eur Urol 2010; 57: 121-31.

Further information: GSK

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