New combination antibiotic for serious infections

Zavicefta (ceftazidime/avibactam) is a new combination antibiotic for the treatment of serious Gram-negative bacterial infections requiring hospitalisation.

Ceftazidime/avibactam is active against pathogens including Enterobacteriaceae and Pseudomonas aeruginosa. | iSTOCK
Ceftazidime/avibactam is active against pathogens including Enterobacteriaceae and Pseudomonas aeruginosa. | iSTOCK

Zavicefta is given by intravenous infusion to treat complicated intra-abdominal infections, complicated urinary tract infections including pyelonephritis, and hospital-acquired pneumonia including ventilator-associated pneumonia. It can also be used in the treatment of aerobic Gram-negative infections in patients with limited treatment options.

Ceftazidime is an established third-generation cephalosporin. The addition of avibactam protects ceftazidime against degradation by bacterial β-lactamases.

According to the manufacturer, Zavicefta has been developed in response to the urgent need for new antibiotics to treat serious infections that are becoming increasingly resistant, such as multi-drug resistant Pseudomonas aeruginosa, carbapenem-resistant Gram-negative pathogens, and ESBL-producing Enterobacteriaceae.


MIMS Clinics

Prescribing news and resources for key therapeutic areas, collated by the MIMS editors.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Alert:
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases

Promo Image

Clinical calculators

Handy calculators and conversions for primary care.