New cardiovascular advice for Strattera

The manufacturer of Strattera (atomoxetine) has clarified the recommendations for cardiovascular assessment before starting treatment.

Pre-existing conditions likely to deteriorate include severe hypertension, advanced heart failure, progressive unstable angina, cardiomyopathies, cerebral aneurysm, stroke and recent or recurrent MI
Pre-existing conditions likely to deteriorate include severe hypertension, advanced heart failure, progressive unstable angina, cardiomyopathies, cerebral aneurysm, stroke and recent or recurrent MI

In an analysis of pooled trial data, investigators noted a clinically significant increase in heart rate and blood pressure in 6-12 per cent of children and adults treated with atomoxetine.

The increase was similar to that observed in patients treated with methylphenidate.

In agreement with the MHRA, the following recommendations have been made:

  • Strattera is contraindicated in patients with severe cardiovascular or cerebrovascular disease that is likely to deteriorate following an increase in heart rate or blood pressure.
  • Strattera should be used with caution if underlying medical conditions could worsen if heart rate or blood pressure increases.
  • Assess patients for cardiac disease before starting Strattera and refer for specialist cardiac evaluation if heart disease is suspected.
  • Measure heart rate and blood pressure before starting treatment, during treatment, after dose adjustment and then at least every 6 months.
Want news like this straight to your inbox?
Sign up for our bulletins

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases