Myocardial ischaemia with beta-agonists

Evidence from post-marketing data and published literature suggest that myocardial ischaemia is associated with the use of short-acting beta-agonists.

In respiratory use, patients with a history of heart disease, including angina or rhythm disturbance, should be advised to continue treatment with short-acting beta-agonists, but to seek advice if symptoms such as shortness of breath or chest pain occur.


In women with significant risk factors for — or who have pre-existing ischaemic heart disease — the risk of myocardial ischaemia outweighs the benefits of use of short-acting beta-agonists such as ritodrine, salbutamol, or terbutaline for the prevention of premature labour. Other treatments (e.g. atosiban) do not carry a similar risk.

In all other patients, short-acting beta-agonists should be used with caution in the prevention of premature labour because of the risk of myocardial ischaemia

Further information: MHRA


Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Register
Already registered?
Sign in

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Alert:
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases