Jetrea: first pharmacological treatment for vitreomacular adhesion

Jetrea (ocriplasmin) is an intravitreal injection for the treatment of vitreomacular traction (VMT), including that associated with macular holes of up to 400 microns diameter.

Treatment with Jetrea in the other eye is not recommended concurrently or within 7 days of the initial injection.
Treatment with Jetrea in the other eye is not recommended concurrently or within 7 days of the initial injection.

PHARMACOLOGY

Ocriplasmin is a truncated form of human plasmin. It has a proteolytic effect on numerous components of the vitreous body and vitreoretinal interface, including collagen, fibronectin and laminin. It is the abnormal binding of these proteins that can result in vitreomacular adhesion (VMA), leading to VMT.

CLINICAL STUDIES

The safety and efficacy of ocriplasmin was evaluated in two multicentre, randomised, double-blind, phase III studies involving 652 adults with VMT. In an analysis of the combined results, the incidence of VMA resolution at day 28 was significantly higher in patients treated with ocriplasmin than in those given placebo (26.5% vs 10.1%, p<0.001).2

With regard to secondary endpoints, total posterior vitreous detachment at day 28 was more common in the ocriplasmin group than in the placebo group (13.4% vs. 3.7%, p<0.001). Non-surgical closure of macular holes was achieved in 40.6% of ocriplasmin-injected eyes, compared with 10.6% of placebo-injected eyes (p<0.001).2 

References:

  1. Jetrea Summary of Product Characteristics, March 2013.
  2. Stalmans P et al. N Engl J Med 2012; 367: 606–15. 

View Jetrea drug record

Further information: Alcon Laboratories

Follow MIMS on Twitter 


MIMS Clinics

Prescribing news and resources for key therapeutic areas, collated by the MIMS editors.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Alert:
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases

Promo Image

Clinical calculators

Handy calculators and conversions for primary care.