Infographic: High levels of antibiotic resistance in paediatric urinary infections

Antibiotic resistance in paediatric urinary tract infections caused by E. coli is widespread, a review published in the BMJ has revealed.

This systematic review included 58 observational studies that investigated 77783 E. coli isolates in urine.
This systematic review included 58 observational studies that investigated 77783 E. coli isolates in urine.

The findings suggest that several antibiotics for children commonly used in primary care, including ampicillin and trimethoprim, could be ineffective first-line treatments for urinary tract infections, especially if there is a history of antibiotic use.

The availability of antibiotics over the counter could be to blame for the particularly high levels of resistance seen in countries outside the Organisation for Economic Co-operation and Development (OECD), according to the researchers.

The study found that bacterial antibiotic resistance can persist for up to 6 months after initial treatment. When antibiotic treatment is needed, the researchers suggest that clinicians consider a child’s antibiotic use in the previous 6 months when selecting further treatment, avoiding the use of broad-spectrum antibiotics whenever possible.

MIMS Clinics

Prescribing news and resources for key therapeutic areas, collated by the MIMS editors.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases

Promo Image

Clinical calculators

Handy calculators and conversions for primary care.