Hormonal Therapies for the Adjuvant Treatment of Early Oestrogen-Receptor-Positive Breast Cancer (TA112)

Technology Appraisal Guidance No. 112

Source: National Institute for Health and Care Excellence

1. Guidance

This applies to the use of the aromatase inhibitors anastrozole, exemestane and letrozole, within the marketing authorisations for each drug at the time of this appraisal, for the treatment of early oestrogen-receptor-positive breast cancer; that is:

  • anastrozole for primary adjuvant therapy
  • exemestane for adjuvant therapy following 2-3 years of adjuvant tamoxifen therapy
  • for primary adjuvant therapy and extended adjuvant therapy following standard tamoxifen therapy.

1.1 The aromatase inhibitors anastrozole, exemestane and letrozole, within their licensed indications, are recommended as options for the adjuvant treatment of early oestrogen-receptor-positive invasive breast cancer in postmenopausal women.

1.2 The choice of treatment should be made after discussion between the responsible clinician and the woman about the risks and benefits of each option. Factors to consider when making the choice include whether the woman has received tamoxifen before, the licensed indications and side-effect profiles of the individual drugs and, in particular, the assessed risk of recurrence.


The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at http://guidance.nice.org.uk/TA112

An abridged version of this guidance (a 'quick reference guide') is also available. Printed copies of the quick reference guide can be obtained by contacting 0845 003 7783 or emailing publications@nice.org.uk and quoting reference number N1150. It is also available on the Internet at http://guidance.nice.org.uk/TA112/quickrefguide/pdf/English

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email: nice@nice.org.uk

Hormonal Therapies for the Adjuvant Treatment of Early Oestrogen-Receptor-Positive Breast Cancer.
Issue Date: November 2006
Review Date: June 2009


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