Epoetin Alfa, Epoetin Beta and Darbepoetin Alfa for Cancer Treatment-Induced Anaemia (TA142)

Technology Appraisal Guidance No. 142

Source: National Institute for Health and Care Excellence

NOTE: This guidance has been replaced by ‘NICE technology appraisal guidance 323’.

1. Guidance

1.1 Erythropoietin analogues are not recommended for routine use in the management of cancer treatment-induced anaemia, except in the circumstances described below.

1.2 Erythropoietin analogues are recommended in combination with intravenous iron as an option for the management of cancer treatment-induced anaemia in women receiving platinum-based chemotherapy for ovarian cancer who have symptomatic anaemia with a haemoglobin level of 8 g/100 ml or lower. The use of erythropoietin analogues does not preclude the use of existing approaches to the management of anaemia, including blood transfusion where necessary.

1.3 Erythropoietin analogues in combination with intravenous iron may be considered for people who cannot be given blood transfusions and who have profound cancer treatment-related anaemia that is likely to have an impact on survival.

1.4 In the circumstances outlined in 1.2 and 1.3, the erythropoietin analogue with the lowest acquisition cost should be used.

1.5 People who are currently being treated with erythropoietin analogues for the management of cancer treatment-related anaemia but who do not fulfil the criteria in 1.2 and 1.3 should have the option to continue their therapy until they and their specialists consider it appropriate to stop. 


The guidance shown above constitutes Section 1 of the full document. A copy of the full document and a summary of the evidence is available on the Internet at http://www.nice.org.uk/guidance/index.jsp?action=byID&o=11990

An abridged version of this guidance (a 'quick reference guide') is also available. Printed copies of the quick reference guide can be obtained by contacting 0845 003 7783 or emailing publications@nice.org.uk and quoting reference number N1563. It is also available on the Internet at http://www.nice.org.uk/guidance/index.jsp?action=download&o=40698

This guidance represents the view of the Institute which was arrived at after careful consideration of the available evidence. Health professionals are expected to fully take it into account when exercising their clinical judgement. This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.

© Copyright National Institute for Health and Care Excellence. All rights reserved. This material may be freely reproduced for educational and not for profit purposes within the NHS. No reproduction by or for commercial organisations is permitted without the express written permission of the Institute.

Enquiries concerning the guidance should be addressed to: National Institute for Health and Care Excellence, MidCity Place, 71 High Holborn, London WC1V 6NA. email: nice@nice.org.uk

Epoetin Alfa, Epoetin Beta and Darbepoetin Alfa for Cancer Treatment-Induced Anaemia.
Issue Date: May 2008
Review Date: February 2009


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