Dosulepin overdose risk

It is estimated that every year, up to 200 people in England and Wales commit suicide or fatally overdose with dosulepin (BAN name dothiepin).

The Commission on Human Medicines has advised that safety concerns due to the toxicity of dosulepin in overdose are sufficient to discourage its use in new patients.

In addition, only specialist-care prescribers should start treatment for patients who have not previously received dosulepin, and prescribers should limit the amount issued per prescription.

A maximum prescription equivalent to two weeks’ supply of 75mg per day should be considered in patients with increased risk factors for suicide

Further information: MHRA

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