Breakyl: first buccal film formulation of fentanyl launched

Meda Pharmaceuticals has launched Breakyl, a buccal film which contains fentanyl and is licensed for the treatment of breakthrough pain in opioid therapy for chronic cancer pain.

If more than one film is required per dose, the Breakyl films should ideally be placed on opposite sides of the buccal mucosa to avoid overlap and ensure full absorption of drug from each film.
If more than one film is required per dose, the Breakyl films should ideally be placed on opposite sides of the buccal mucosa to avoid overlap and ensure full absorption of drug from each film.

The product consists of a small rectangular dissolvable film with a pink side that contains fentanyl and a white side which has been designed to minimise fentanyl release into the saliva to avoid swallowing of the active substance. The patient should moisten the inside of the cheek with saliva or by rinsing with water and then press the pink side of the film against the inside of the cheek for a minimum of 5 seconds. The film should adhere and stay in place for 15 to 30 minutes until it has dissolved completely.

The recommended initial dose of Breakyl is 200 microgram, titrated upwards as necessary. Each dose of Breakyl must be separated by at least 4 hours; if adequate pain relief is not observed, alternative rescue medication can be administered and the next highest strength of Breakyl should be administered for the next episode of breakthrough pain.

View Breakyl drug record

Further information: Meda

Follow MIMS on Twitter


MIMS Clinics

Prescribing news and resources for key therapeutic areas, collated by the MIMS editors.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Alert:
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases

Promo Image

Clinical calculators

Handy calculators and conversions for primary care.