Available caffeine citrate products not equivalent, warns MHRA

In a letter to healthcare professionals, the MHRA has highlighted that there are two different strengths of caffeine citrate preparation available.

Monitoring of plasma caffeine concentration is recommended during treatment with caffeine citrate | SCIENCE PHOTO LIBRARY
Monitoring of plasma caffeine concentration is recommended during treatment with caffeine citrate | SCIENCE PHOTO LIBRARY

Caffeine citrate is used in neonatal intensive care units to treat primary apnoea in premature infants. Clinicians should note that the strength of caffeine citrate in the branded product Peyona (20mg/ml) is twice that of some generic products currently available (10mg/ml). Prescribers should take careful note of which product is being used to prevent dosing errors.

It is also important to check whether the dose is expressed in terms of the salt (caffeine citrate) or as caffeine base.

Further information:

Drug Safety Update June 2012

View Peyona drug record
View Caffeine citrate drug record


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