A topical treatment containing ASE and other lenitive and antioxidant ingredients was applied twice daily for 24 weeks.
A supplement containing ASE, vitamin E and para-aminobenzoic acid was also given for the first 12 weeks.
The rate of participants achieving an improvement from baseline of at least 75% in global subjective score (GSS75) and global objective score (GOS75), and those reaching GSS50 and GOS50, was measured.
After 24 weeks, 12 patients (70.5%) achieved GSS75 and 13 (72.2%) achieved GOS75; 100% achieved GSS50 and 88.9% achieved GOS50. Treatment was well tolerated.
The study concluded that treatments containing ASE were effective in treating mild to moderate vulvar lichen sclerosus.
Borghi A, Corazza M, Minghetti S et al. J Eur Acad Dermatol Venereol September 4 2014. doi: 10.1111/jdv.12617