Dysfunctional cells in skin disorders

Regulatory T cells (Tregs) control the immune responses and prevent autoimmunity

After identifying a subset of skin-specific Tregs with properties typical of memory cells (mTregs) in mice, researchers at the University of California, US, analysed the mTreg population in human skin due to their importance in the regulation of tissue inflammation.

They found that human mTregs have unique features and localise to hair follicles in healthy skin. mTregs did not appear to recognise the same antigens as memory T cells isolated from blood. In healthy skin, mTregs were relatively static. However, in inflamed skin from patients with psoriasis, mTregs expanded and were highly proliferative.

The study suggests that mTregs are dysfunctional in inflammatory skin conditions. Further studies of Tregs in tissues and the factors that influence their maintenance and functions in health and disease are an essential next step in trying to understand how immune responses are regulated.

Rodriguez RS, Pauli ML, Neuhaus IM et al. J Clin Invest 2014; 124(3): 1027-36


Read these next

1 CPD credit: Allergy: Types of hypersensitivity reaction

1 CPD credit: Allergy: Types of hypersensitivity reaction

Hypersensitivity manifests in many ways. Professor...

1 CPD credit: Second-line treatment for patients with psoriasis

1 CPD credit: Second-line treatment for patients with psoriasis

Options include phototherapy and non-biological systemic...


MIMS Clinics

Prescribing news and resources for key therapeutic areas, collated by the MIMS editors.

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Alert:
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases

Promo Image

Clinical calculators

Handy calculators and conversions for primary care.