Researchers in China looked at the efficacy of a lipoxin A4 based cream compared with a corticosteroid and placebo cream in 60 infants with eczema treated for a total of 10 days.
The potency of lipoxin A4 was shown to be comparable to topical steroid treatment. Use of lipoxin A4 treatment improved quality of life scores. When compared with baseline levels, treatment with lipoxin A4 had reduced redness and itch at day three after treatment, papulation, blistering and scaling at day five and lichenification at day 10 after treatment. The efficacy of the treatment was shown to be persistent for at least one week.
No clinical adverse event was recorded in any of the treatment groups. However, the researchers concluded that further investigation of the clinical use of lipoxin A4 is needed because 'some of the side-effects of lipoxin A4 would be found only in studies with large sample size'.
Wu SH, Chen XQ, Liu B et al. Br J Dermatol 2013; 168: 172-8