Allergy link to CLOCK genes

Mutations in genes that regulate the body's sense of time may trigger severe allergic reactions by disrupting hormonal rhythms, research suggests

Researchers found that mice with damaged CLOCK genes, which govern the body's natural rhythms, such as the sleep-wake cycle, developed severe contact hypersensitivity.

Mice with the faulty genes had severe inflammation, ear swelling and high levels of serum immunoglobulin E and mast cells - which promote contact allergy - compared with normal mice.

Corticosterone, which protects against such immune response, was lower among mutated mice.

The study authors said the findings suggested a role for CLOCK mutations in promoting an immune response that exacerbates contact hypersensitivity.

Takita E, Yokota S, Tahara Y et al. Br J Dermatol 2013; 168: 39-46

Read these next

Reducing risk of allergic disease

Introducing infants to certain foods early in life...

Diagnosing food allergy in children

Oral food challenges remain the gold standard for diagnosing...

Egg allergy, eczema and peanut allergy

Infants with egg allergy and severe eczema are also...

Have you registered with us yet?

Register now to enjoy more articles and free email bulletins

Already registered?
Sign in

Register or Subscribe to MIMS

GPs can get MIMS print & online and GPonline for free when they register online – take 2 minutes, and make sure you get your free MIMS access! If you're not a GP, you can subscribe to MIMS for full access.

Register or subscribe

MIMS bulletins

News and updates straight to your inbox.

Prescribing Update: Fortnightly news bulletin
Urgent prescribing updates
Spotlight: Disease-themed monthly round-up

Sign me up

MIMS Dermatology

Read the latest issue online exclusively on MIMS Learning.

Read MIMS Dermatology

MIMS Adviser

Especially created for prescribing influencers.

Request free copy

Mobile apps

MIMS: access the full drug database and quick-reference tables on the go

MIMS Diagnosis and Management: concise information on signs and symptoms, investigations and diseases