Provoked vestibulodynia is the most common form of vulvodynia and involves muscular anomalies. Few studies have investigated the efficacy of botulinum toxin A in vulvodynia, although it has been evaluated for vaginismus and pelvic floor spasm.
In this study, 20 patients with provoked vestibulodynia received injections of 50U botulinum toxin A bilaterally. The authors investigated pain, quality of life and sexual function. After three months, pain symptoms improved in 80 per cent of patients. During the first six months, patients experienced significantly improved quality of life and sexual function. Botulinum toxin A was shown to be an effective treatment for provoked vestibulodynia.
Pelletier F, Parratte B, Penz S et al. Br J Dermatol 2011; 164: 617-22