Sunitinib for the First-Line Treatment of Advanced and/or Metastatic Renal Cell Carcinoma
Technology Appraisal Guidance No. 169 Source: National Institute for Health and Clinical...
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† if HDL unknown, assume 1.1 in Males, 1.4 in Females
* CHD Event: Coronary Death, Myocardial Infarction, Angina.
** 'Ideal' risk represents:
This risk assessment only applies to assessment for Primary Prevention of CHD, in people who do not have evidence of established vascular disease.
Patients who already have evidence of vascular disease usually have a >20% risk of further events of over 10 years, and require vigorous Secondary Prevention.
People with a Family History of premature vascular disease are at higher risk than predicted; Southern Europeans and some Asians may have a lower risk in relation to standard risk factors.
The MIMS cardiac risk calculator is based on data from the Framingham study published in Circulation in 1998.1
The National Institute for Health and Clinical Excellence (NICE) Guideline on the Management of Hypertension in Adults in Primary Care, updated in 2006,2 recommends that cardiovascular risk is estimated according to the Joint British Societies CVD risk assessment programme/risk charts. These are available on the BHS web site at http://www.bhsoc.org/.
References
1. Prediction of coronary heart disease using risk factor categories. Wilson PWF, et al. Circulation (1998;97;1837-47).
2. Hypertension: Management of hypertension in adults in primary care. NICE Clinical Guideline 34 (June 2006) (partial update of NICE Clinical Guideline 18). http://www.nice.org.uk
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